2009年成都市甲型H1N1流感疫苗免疫效果评价

Evaluation on Vaccination Against 2009 Pandemic Influenza A (H1N1) Virus Infection in Chengdu,2009

目的评估成都市2009年甲型H1N1流感疫苗的免疫效果。方法在6个监测点选择3～11岁、12～17岁学生,18～60岁、>60岁社区居民,用微量血凝抑制试验方法测定甲流抗体。结果监测对象H I抗体阳转率为71.46%,H I抗体达保护性水平比例为75.86%,免后GMT为72.32,GMT增长倍数为23.78倍。3～11岁、>60岁组H I抗体阳转分别为59.52%、58.06%;H I抗体达保护性水平比例为64.29%、60.54%;免后GMT分别为39.66、42.07;GMT增长倍数分别为10.99、25.24倍。结论各年龄组疫苗免疫效果存在差异。3～11岁、>60岁组免疫效果较其他2组差。

Objective To evaluate the effect of the vaccine to 2009 pandemic influenza A（H1N1） in Chengdu in 2009.MethodsThe micro hemagglutination inhibition assay was conducted to detect antibody to 2009 pandemic influenza virus among the community people aged 3-11,12-17,10-60 and 60 years in six surveillance sites.ResultsThe antibody positive conversion rate was 71.46%,the proportion of the vaccinees whose antibody level reached protection level was 75.86%,the GMT post-vaccination was 72.32,which increased 23.78 times.In age group of 3-11 years and60 years,the antibody positive conversion rates were 59.52% and 58.06% respectively,the proportions of those with antibody level reached protection level were 64.29% and 60.54% respectively,and the GMT post-vaccination were 39.66 and 42.07 respectively,which increased 10.99,25.24 times respectively.ConclusionThe effect of vaccination varied by age group,which were better in age groups of 12-17 and 18-60 years than in age groups of 3-11 and 60 years.