慢性阻塞性肺疾病小气道常规肺功能与脉冲振荡法相关性分析

The correlative analysis between small airway funtiong and impulse oscillometry in patients with chronic obstructive pulmonary disease

目的探讨慢性阻塞性肺疾病共振频率(Fres)及周边气道粘性阻力(R5-R20)与小气道功能相关性,进一步探讨小气道变化敏感指标。方法选择我院2007年1月至2010年4月148例慢性阻塞性肺疾病缓解期患者,Fres、R5-R20与小气道功能相关性分析,并随访1年49例慢性阻塞性肺疾病患者小气道功能及Fres、R5-R20行配对t检验。结果 Fres、R5-R20与FEF50%Pred、FEF75%Pred、MMEF%Pred明显负相关(P<0.01),随访1年49例患者,FEF50%Pred、Fres、R5-R20有统计学意义(P<0.05),FEF75%Pred、MMEF%Pred无统计学意义(P>0.05)。结论 Fres、R5-R20与小气道功能有显著相关性,FEF50%Pred、Fres、R5-R20可为观察小气道变化敏感指标。

Objective To study the relationship small airway and Fres,R5-R20 in patients with chronic obstrctive pulmonary disease（COPD）,and to investigate the sensitive index of small airway change.Methods148 cases of COPD in remission stage from January 2007 to April 2010,the relationship small airway and Fres,R5-R20,and 49 cases were observed 1 yeare to design the measured data and analyze them as pairs byt-est.ResultsFres,R5-R20 were negatively correlated to FEF50%Pred、FEF75%Pred、MMEF%Pred（P0.01）.There was statistical significance in FEF50%Pred、Fres、R5-R20（P0.05）,and not statistical significance in FEF75%Pred、MMEF%Pred.ConclusionsThere was satisfactory relationship between small airway and Fres,R5-R20,in patients with chronic obstrctive pulmonary disease（COPD）,and FEF50%Pred、Fres、R5-R20 were he sensitive index of small airway change.