高危医务人员结核病潜在感染的状况和实验室监测指标分析

The status of tuberculosis latent infection and analysis to laboratory monitoring indicators in high-risk medical staff

目的通过对高危医务人员,以了解分析结核病潜伏性感染的状况。方法对活动性结核组、高危医务人员组和普通人群组分别进行结核菌素试验、血液结核抗体测定和进行ESAT-6和CFP-10蛋白刺激T淋巴细胞分泌IFN-γ试验,并结合病原学和影像学检查,分析高危医务人员潜在感染结核病的状况。结果高危医务人员与活动性结核患者结核菌素试验阳性率无显著差异;而高危医务人员组结核抗体阳性率显著低于活动性结核组和高于普通人群组,ELISPOT法能区别BCG接种出现的阳性反应,可代替TST对结核进行早期诊断,并有助于发现高危医务人员中潜在的活动性结核。结论 ELISPOT为诊断潜伏性活动性结核的最佳试验方法。

Objective The analysis to laboratory monitoring indicators was applied to understand the status of tuberculosis latent infection in high-risk medical staff.MethodsTuberculin test and TB antibody test,and esat-6 and cfp-10 proteins to stimulate T cell secretion of IFN-γeffect test were applied to the groups of active TB and high-risk medical staff and general population,combined with etiology and radiographic examination,the status of tuberculosis latent infection in high-risk medical staff was analyzed.ResultsThere was no significant difference between the groups of active TB and high-risk medical staff;the positive rate of TB antibody in high-risk medical staff was significant lower than in active TB;ELISPOT method can distinguish the positive reaction from BCG vaccination,and Can replace the TST for early diagnosis of tuberculous,and can help to identify potentially high-risk medical staff in active TB.ConclusionELISPOT method is the best test for the diagnosis of Latent active TB.