VEGF、CEA、CA153联合检测在恶性胸腔积液中的诊断价值

Combined assays of tumor marker VEGF、CEA、CA153 for differential diagnosis of pleural effusion

目的评价胸腔积液VEGF、CEA、及CA153联合检测对恶性胸腔积液鉴别诊断价值。方法采集胸腔积液患者胸水样本80例,其中恶性胸腔积液患者50例,良性胸腔积液患者30例,应用ELISA方法及化学发光法检测标本中VEGF、CEA和CA153的水平。结果恶性胸腔积液组VEGF、CEA、及CA153水平明显高于良性胸腔积液组(P<0.01),VEGF、CEA、及CA153联合检测可使鉴别诊断敏感性明显提高,诊断恶性胸腔积液的敏感度为94.28%,特异度为76.93%。结论肿瘤标志物CEA、CA153和CY211的联合检测,对胸腔积液的鉴别诊断有较好的临床价值,联合方式以VEGF+CEA为佳。

Objective To study the clinical significance of tumormarkers combined assay in the differential diagnosis of pleural effusion.Methods80 hydrothorax samples were collected from 80 in-patients with pleural effusion.Among them,50 patients were suffered with malignant pleural effusion and 30 patients with benign pleural effusion.The concentration of VEGF 、CEA、and CA153 was determined by ELISA and chemiluminescence.ResultsVEGF、CEA、and CA153 in malignant group were significantly higher than that in benign pleura effusion group（P0.01）.The sensitivity of combined assay with hydrothorax VEGF、CEA and CA153 in diagnosing malignant pleural effusion was proved.Conclusion Tumormarkers of VEGF、CEA、and CA153 have high clinical values in the differential diagnosis of pleural effusion.The combined assaywith VEGF＋CEA is recommended.