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呼吸道乳头状瘤癌变1例及文献复习

The review of literature with a case of juvenile laryngeal papilloma(JLP)
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摘要 目的探讨呼吸道乳头状瘤癌变的病因,临床特点、病理及病理生理机制等。方法结合收治1例患者的临床资料及近10年国内外已发表有较完整临床资料的患者,就其病因、临床特点及病理表现进行综合分析。结果人乳头状瘤病毒(HPV)感染为呼吸道乳头状瘤主要病因,其中HPV-16,18密切相关。该疾病具有生长快、多发性及易复发等临床特点,少数发生癌变,即鳞状细胞癌。已发现p53、Rb蛋白p21、EGFR-STAT3等多种蛋白基因与恶变相关。结论呼吸道乳头状瘤病因、临床表现及病理生理等均有一定特点,癌变者为少数,确诊有赖于病理,基因检测也有助于诊断。 Objective To investigate the reason,clinical,of juvenile laryngeal papilloma（JLP）.Methods1 case of JLP in PLA General Hospital was retrospectively analyzed and the literature published in the last ten years were reviewed.ResultsSquamous cell carcinoma arise from extensive respiratory papilomatosis.Human papilloma virus is associated with respiratory papillomatosis,and HPV-16,18-associated JLP malignant transformation.ConclusionsThe clinical,pathophysiology of JLP is characteristic.The diagnosis depends on pathology.
作者 左震华 赵铁梅 管希周 邵汇琳
机构地区 解放军总医院呼吸科 解放军总医院病理科
出处 《临床肺科杂志》 2011年第4期569-571,共3页 Journal of Clinical Pulmonary Medicine
关键词 人乳头状瘤病毒 乳头状瘤 癌变 Human papilloma virus Papillary epithelioma Malignant transformation
分类号 R739.65 [医药卫生—肿瘤]
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参考文献16

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临床肺科杂志
2011年 第4期

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