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结缔组织生长因子(CTGF)与肺纤维化的关系研究进展 被引量：7

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摘要 肺纤维化（pulmonary fibrosis,PF）是由多种原因引起慢性肺疾病的共同结局,是呼吸衰竭的主要病理基础,其病理特点是肺部炎症导致肺泡持续性损伤及细胞外基质的反复破坏修复、重建和过度沉积。随着对肺纤维化发生机制研究的不断深入，已认识到各种细胞释放的细胞因子、生长因子、前炎症介质和趋化因子等生物活性分子在肺纤维化发生发展中的重要意义。在参与肺纤维化的细胞因子中，
作者 高媛 秦军
机构地区 兰州军区乌鲁木齐总医院
出处 《临床肺科杂志》 2011年第4期601-601,606,共2页 Journal of Clinical Pulmonary Medicine
关键词 结缔组织生长因子 肺纤维化 生物活性分子 细胞因子 慢性肺疾病 细胞外基质 前炎症介质 病理基础
分类号 R563.9 [医药卫生—呼吸系统]
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参考文献15

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  • 2Bradham DM, Igarashi A, Potter R,et al. Connective tissue growth factor:a cydteine-rlch mitogcn secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10[ J]. J Cell Biol ,2007,114(6) :1285 - 1294.
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临床肺科杂志
2011年 第4期

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