酒依赖患者认知功能障碍的临床研究

Study of the cognitive impairment in alcoholics

目的：了饵酒依赖患者认知功能的损害情况。方法：利用威斯康星卡片分类测验（WCST）对30例已完成戒断治疗的男性酒依赖患者和30例匹配的正常对照者进行认知功能的评定，比较两组之间的差异。结果：1、Wisconsin卡片分类测验（WCST）两组间总应答数（t=4．76）、分类数（t=5．21）、正确应答百分数（t=4．82）、错误应答数（t=4．77）、持续应答数（z=4．64）、持续性错误数（z=4．48）、概念化应答百分数（t=5．21）、完成第一类所需应答数（t=3．63）的比较均显示，酒依赖组成绩较非依赖组差（P〈0．01）。2、相关因素分析：威斯康星卡片分类测验结果提示，饮酒时间与总应答数、错误应答数、持续性错误数呈正相关（r=0．34～0．38，P〈0．05），与正确应答百分数、概念化水平应答百分数呈负相关（r=-0．35，P〈0．05），其它均无相关性。结论：酒依赖者存在认知功能损害。

Objective：To study the cognitive impairment of patients with alcohol dependence. Methods：30 patients with alco- hol dependence one week after detoxification and 30 normal controls evalute cognitive function with WCST. Results： There were significant difference between the two groups with WCST in the following items （P 〈 0.01 ） ：Number of categories, percentage of correct re- sponses, number of error answers, number of preservation of responses, number of preservation errors, percentage of conceptive level responses. 2,Data analysis indicated that the cognitive impairment of alcoholics was closely correlated with years of drinking. Conclu- sions： Alcohol dependence has cognitive impairment.