43例扎来普隆分散片治疗老年失眠症的对照研究

A comparative study of Zaleplon dispersible in the treatment of elderly insomnia

目的：比较扎来普隆分散片治疗老年失眠症的有效性及安全性。方法：将86例老年失眠症患者随机分为扎来普隆分散片组和佐匹克隆组各43例，治疗剂量分别为5～10mg,／d和7．5～15mg,／d，两组疗程均为2周。采用睡眠障碍量表（SDRS）评定疗效，采用药物不良反应量表（TESS）评价不良反应。结果：治疗结束时，两组SDRS评分均较治疗前显著减少（P〈0．05）。扎来普隆分散片组有效率为69．76％，佐匹克隆组为62．79％，两组比较差异无显著性意义（P〉0．05）。不良反应分析显示扎来普隆分散片较常见不良反应为口干、头昏、恶心、头痛等，未出现严重不良反应。结论：扎来普隆分散片治疗老年失眠症安全有效。

Objective：To explore the efficacy and safety of Zaleplon dispersible in the treatment of elderly insomnia. Methods：A total of 86 patients with insomnia were randomly divided into Zaleplon dispersible group （5 - 10 mg/d） （n = 43 ） and Zopicolone group （7.5 - 15 mg/d） （n = 43 ）for 2 weeks. The clinical efficacy and side effects were evaluated with the Sleeping Dysfunction Rating Scale （SDRS）and Treatment Emergent Symptoms Scale （TESS）. Results： Both groups showed significant improvement in the score of SDRS after treatment（ P 〈 0.05 ）. The effective rates of Zaleplon dispersible group and Zopicolone group were 69.76% and 62.79% , and there was no significant difference between two groups. The common adverse reactions in Zaleplon dispersible group were dry mouth, dizziness, nausea and headache. Conclusions： Zaleplon dispersible is effective and safe for treating elderly insomnia.