ER、PR、Ki-67和p53在子宫内膜癌的表达及其临床意义

Expression of ER, PR, Ki-67 and p53 in Endometrial Carcinoma and Their Clinical Significance

[目的]探讨ER、PR、Ki-67和p53在子宫内膜癌组织中的表达及其临床意义.[方法]应用免疫组织化学技术检测在20例正常子宫内膜（A组）、20例子宫内膜非典型增生（B组）及102例子宫内膜癌（C组）的ER、PR、Ki-67 及p53表达,分析其表达及与临床分期、组织学分级、肿瘤肌层浸润及淋巴结转移的相关性.[结果]A组、B组及C组中的p53和Ki-67表达阳性率逐渐升高且统计学处理差异有显著性（P＜0.01）,而ER 、PR表达相反;在子宫内膜癌中p53、Ki-67的表达与ER、PR的表达呈负相关.ER、PR、p53、Ki-67在子宫内膜癌中的表达与临床分期、组织学分级、肿瘤肌层浸润及淋巴结转移密切相关.[结论]对子宫内膜癌进行ER、PR、p53及Ki-67的检测,有助于预测子宫内膜癌的发生、演进、转移及预后.

[Objective] To explore the expression and clinical significance of ER, PR, Ki-67 and p53 in endometrial carcinoma. [Methods] lmmunohistochemical method was used to detect the expression of ER, PR, Ki-67 and p53 in 20 normal endometrial tissues（group A）, 20 cases of atypical hyperplasia endometr/um（group B） and 102 cases of endometrial carcinoma（group C）. The relationship between the expression and clinical stage, histological grade, muscular invasion or lymph node metastasis was analyzed. [Results] The positive expression rate of p53 and Ki-67 in group A, B and C increased gradually, and there was significant difference （P〈0.01）, while the expression of ER and PR were opposed. The expression of p53 and Ki-67 inendometrial carcinoma were negatively correlated with the expression of ER and PR. The expression of ER, PR, p53 and Ki-67 in endometrial carcinoma were correlated closely with clinical stage, histological grade, muscular invasion and lymph node metastasis. [Conclusion] Detection of ER, PR, p53 and Ki 67 in endometrial carcinoma may be helpful to predict the pathogenesis, progression, metastasis and prognosis of endometrial carcinoma.