HLA-DRB1＊0701/02、DRB1＊1201/02等位基因与新疆维吾尔族白癜风相关性研究

Association of HLA-DRB1＊0701/02, DRB1＊1201/02 Alleles with Vitiligo in Xinjiang Uygur Region

[目的]探讨人类白细胞抗原（HLA-DRB1＊0701/02、DRB1＊1201/02）等位基因与新疆维吾尔族白癜风相关性.[方法]应用聚合酶链反应-序列特异性引物（PCR-SSP）技术检测300例维吾尔族白癜风患者（白癜风组）和300例维吾尔族健康者（对照组）的HLA -DRB1＊0701/02、DRB1＊1201/02等位基因,比较两组基因频率及分布频率.[结果]白癜风患者DRB1＊0701/02、DRB1＊1201/02等位基因频率显著高于对照组（P〈0.05） 儿童型发病、成人型发病、无家族病史型、局限型、泛发型、进展期的白癜风患者的HLA-DRB1＊0701/02和DRB1＊1201/02等位基因频率均显著高于对照组（P〈0.05） 有家族史和稳定期白癜风患者HLA-DRB1＊0701/02等位基因频率与正常对照组相比较有显著性差异（P〈0.05）,有家族史和稳定期白癜风患者DRB1＊1201/02与对照组相比无显著性差异（P＞0.05）.[结论]HLA -DRB1＊0701/02、DRB1＊1201/02 等位基因可能是新疆维吾尔族白癜风的易感基因.

[Objective] To explore the relationship between HLA-DRB1＊ 0701/02, DRB1 ＊1201/02 alleles and vitiligo in Xinjiang Uygur region. [Methods]Polymerase chain reaction sequence-speeifie primer （PCR-SSP） was used to detect HLA DRB1＊ 0701/02 and DRB1＊ 1201/02 alleles in 300 vitiligo patients in Xinjiang Uygur region（Vitiligo group） and 300 healthy people（control group）. The gene frequency and distribution frequency were compared between two groups. [Results] The frequencies of HLA-DRB1 ＊ 0701/02 and HLA-DRB1 ＊ 1201/02 alleles in vitiligo group were significantly higher than those in the control group（ P〈0.05）. The frequencies of HLA-DRB1＊ 0701/02 and HLA-DRB1 ＊ 1201/02 alleles in vitiligo patients with childhood-onset, adulthood-onset, negative family history, fo cal-type, generalized-type or progressive phase were significantly higher than those in control groups（ P〈0.05）. And there was significant difference in the frequency of HLA-DRB1＊0701/02 alleles between vitiligo patients with family history and in stable phase and the normal control group（ P〈0.05）, but there was no significant difference in the frequency of HLA-DRB1 ＊ 1201/02 alleles between vitiligo patients with family history and in stable phase and the control group（ P〈0.05）. [Conclusion] HLA-DRB1 ＊ 0701/02 and DRB1 ＊ 1201/02 alleles may be the suscep tible alleles in Xinjiang Uygur region.