短期胰岛素泵治疗初诊2型糖尿病的疗效

Efficacy of Short-term Insulin Pump for the Treatment in Newly Diagnosed Type-2 Diabetes Mellitus

[目的]评价持续皮下胰岛素输注（CSII）强化治疗新诊断的2型糖尿病患者的有效性和安全性.[方法]新诊断的2型糖尿病住院患者120例,随机分成两组：CSII组60例,采用胰岛素泵持续皮下输注胰岛素 多次皮下胰岛素注射 （MSII）组60例,采用胰岛素笔注射胰岛素.观察两组空腹血糖（FPG）、餐后2 h血糖（P2hPG）、糖化血红蛋白（HbAlc）、血糖达标时间、胰岛素用量、低血糖次数等,比较两组间疗效差异.[结果]治疗前两组FPG及P2 hPG、HbAlc组间比较无统计学差异（P〉0.05）,两组治疗后FPG和P2 hPG、HbAlc均较治疗前显著下降（P〈0.05）.CSⅡ组血糖达标时间（4.85±0.61）d较MSⅡ组血糖达标时间（6.02±0.68）d明显缩短（P〈0.05）,胰岛素用量（40.77±3.26） U/d与MSII组（46.35±4.04） U/d相比有显著差异（P〈0.05）,低血糖次数较MSII组显著减少（P〈0.05）.[结论]对于新诊断的2型糖尿病患者,短期应用胰岛素泵强化治疗较多次皮下胰岛素注射法更有效安全.

[Objective]To evaluate the efficacy and safety of short-term continuous subcutaneous insulin infusion （CSⅡ） intensification therapy for the treatment in newly diagnosed type 2 diabetic patients. [Methods] Totally 120 patients were randomly divided into CSII group（ n = 60） and multiple subcutaneous insulin infusion（MSⅡ） group（ n 60）. The fasting plasma glucose, postprandial 2h plasma glucose, glyeated hemoglobin, target time, insulin dosage and hypoglycemic rates were observed in two groups. [Results] There was no significant difference in fasting plasma glucose, postprandial plasma glucose and glycated hemoglobin between the two groups before treatment（ P〉0.05）. Compared with before treatment, fasting plasma glucose, postprandial plasma glucose and glycated hemoglobin in two groups after treatment decreased significantly（ P〈0.05）. The target time of blood glucose[（4.85 ± 0.61）d] in CSⅡ group was shorter than that in MSⅡ group[（6.02±0.68）d]（ P〈0.05）. There was significant difference in insulin dose[（40.77±3.26） U/d vs 46.35±4.04） U/d] between two groups（ P〈0.05）. The hypoglycemic rate of CSⅡ group was also decreased obviously than that of MSⅡ group（ P〈0.05）. [Conclusion] Short-term insulin pump in tensification therapy for the treatment of the newly diagnosed type 2 diabetic patients is more effective and safer than multiple subcutaneous insulin infusion.