子宫动脉血流异常频谱与晚发型子痫前期患者围产期结局的相关性研究

Relationship Between Abnormal Doppler Frequency of Uterine Artery Flow and Peripartum Outcome of Late-onset Preeclampsia Patients

[目的]探讨晚发型子痫前期患者子宫动脉血流异常频谱对围产期结局的影响.[方法]观察136例晚发型子痫前期患者子宫动脉血流彩色多普勒频谱,根据子宫动脉阻力指数（RI）和是否存在舒张早期切迹进行分组,对比各组之间围产期不良结局发生率.[结果]频谱正常组52例（RI〈0.61,无舒张早期切迹）、异常频谱1组49例（RI≥0.61,无舒张早期切迹）和异常频谱2组35例（RI≥0.61,或存在舒张早期切迹）.子宫动脉RI≥0.61或存在舒张早期切迹是早产、死胎、新生儿低出生体重和小于胎龄儿、出生5 min时Apgar评分小于7分和缺血缺氧性脑病等围产期不良结局的危险因数.[结论]对晚发型子痫前期患者常规进行子宫动脉血流频谱测定有助于预测围产期不良结局.

[Objective] To explore the effect of abnormal Doppler frequency of uterine artery flow on the peripartum outcome of late-onset preeclampsia patients. [Methods] The Doppler frequency of uterine artery flow of 136 patients with late-onset preeclampsia were observed. According to the uterine artery flow resistance index（RI） and early diastolic notch, all patients were grouped. The incidence of peripartum poor outcome was compared among groups. [Results]All patients were divided into normal Doppler flow group（ n =52, RI （0.61, without early diastolic notch）, abnormal Doppler flow group Ⅰ （ n =49, RI≥0.61, without early diastolic notch） and abnormal Doppler flow groupⅡ （ n =35, RI≥0.61 or with early diastolic notch）. Uterine artery flow RI≥0.61 or early diastolic notch was the risk factors of peripartum poor outcomes such as premature, fetal death, low birth weight of newborn, small-for-date infant, 5rain Apgar score（7 and hypoxic-ischemic encephalopathy, etc. [Conclusion]The Doppler imaging of uterine artery flow is helpful for predicting peripartum outcome of patients with late-onset preeclampsia.