高血压病患者血浆ET-1/CGRP的含量变化及其临床意义

Clinical significance of changes of ET-1 /CGRP in different blood pressure grade in essential hypertension

目的探讨不同血压分级高血压病(EH)患者血浆内皮-素1(endothelin-1,ET-1)、降钙素基因相关肽(cal-cium gene related peptide,CGRP)的水平变化,以阐明其在高血压病中的作用。方法 120例EH患者按1999年WHO/ISH对高血压的诊断和血压分级标准分为EH 1级、2级、3级组各40例;另选正常人(对照组)40例,分别检测血浆内皮素-1(ET-1)、降钙素基因相关肽(CGRP)。结果不同血压分级高血压病患者血浆ET-1、CGRP的浓度与正常人相比均有显著性差异(P<0.01),各组ET-1、CGRP两两比较均有统计学意义(P<0.05),随着高血压病级别的升高CGRP呈进行性下降,血浆ET-1呈进行性增高。结论随着高血压病的进展,血浆ET-1含量升高,CGRP含量降低,且与高血压病变严重程度有着一定关联,血浆含量检测有助于判断病情的程度。

Objective To illustrate the effects of endothelin-1（ET-1） and calcitonin gene related peptide（CGRP） in different blood pressure grade in essential hypertension.Methods The study was carried out on 120 patients with EH according to the 1999 WHO/ISH Guidelines for the management of Hypertensian.The patients with EH were divided in three groups： grade one（n=40）,grade two（n=40） and grade three（n=40）.40 healthy subjects were recruited as normal controls.The plasma levels of ET-1 and CGRP were measured.Results EH patients with different blood pressure grade with plasma ET-1,CGRP concentrations were compared with the normal significant difference（P0.01）,each group ET-1,CGRP pairwise comparisons were statistically significant（P0.05）.With the progress of EH CGRP decreased progressively,plasma ET-1 was progressive increase.Conclusion With the progress of EH CGRP decreased progressively,plasma ET-1 was progressive increase,and correlate to the severity of the disease,measuements of their plasma concentrations help to pre-dict these verity of the disease.