山东省部分人群甲型H1N1流感血清抗体水平研究

Analysis on serum antibody level to pandemic influenza A(H1N1) virus in some population in Shandong province

目的了解甲型H1N1流感大流行季节山东省甲型H1N1流感抗体水平，分析甲型H1N1流感病毒感染状况。方法2010年1月10日、25日、2月20日和3月20日随机选择山东省2家医院门诊就诊人群和血站献血人员分年龄组采集1617人份静脉血，采用血凝抑制试验检测甲型H1N1流感血清抗体水平进行分析。结果山东省4次甲型H1N1流感血清抗体阳性率和抗体几何平均滴度（GMT）分别为18．24％（GMT13．86）、26．95％（GMT16．65）、30．33％（GMT17．74）和11．53％（GMT12．72）；0～5岁、6～17岁、18～55岁和≥56岁4个年龄组中甲型H1M流感病毒血清抗体阳性率分别为26．88％、30．72％、19．03％和10．38％。结论山东省部分人群对甲型H1N1流感病毒抗体水平逐步升高，但仍未达到免疫保护水平。2月山东省甲型H1N1流感抗体阳性率和GMT最高，6～17岁年龄组人群抗体阳性率较其他年龄组高。

Objective To understand the antibody level to pandemic influenza A （H1N1） virus and analyze the infection status in population in Shandong. Methods A total of 1617 serum specimens were collected from outpatients and blood donors at 10 January, 25 January, 20 February and 20 March in 2010, the serum antibody to pandemic influenza A （ HI N1 ） virus was detected by hemagglutination-inhibition （HI） test. Results The 4 surveys indicated that antibody positive rate and GMT were 18.24% and 13.86, 26.95% and 16. 65, 30. 33% and 17.74, 11.53% and 12.72 respectively; The antibody positive rates in 4 age groups were 26. 88% （0 - 5 years old）, 30. 72% （6 - 17 years old）, 19. 03% （ 18 -55 years old） and 10. 38% （ 1〉 56 years old）. Conclusion The antibody level to pandemic influenza A （HI N1 ） virus in some population in Shangdong increased steadily, but it had not reached protective level. The highest antibody positive rate （30. 33% ） and GMT （17.74） were detected in February in 2010, and the antibody positive rate was highest in age group of 6 - 17 years old.