摘要
目的:对镇惊定志合剂的抗抑郁作用进行动物实验研究。方法:40只雄性SD大鼠随机分为4组,即对照组、抑郁模型组、镇惊定志合剂组和氟西汀组,每组10只大鼠。采用慢性缓和性应激和孤养建立抑郁模型,观测镇惊定志合剂的抗抑郁效果。结果:镇惊定志合剂可明显增加大鼠开野实验的水平和垂直活动次数(P<0.05),并提高蔗糖水摄入量(P<0.05)。结论:镇惊定志合剂具有有效的抗抑郁作用。
Objective： To study the anti-depression effect of Zhenjing-dingzhi（ZJDZ） Decoction on animal model of depression.Methods： Forty male Sprague-Dawley rats were randomly divided into 4 groups,which were normal control group（n=10）,depression model group（n=10）,ZJDZ decoction group（n=10） and Fluoxetine group（n=10）.The depression model of rat was established by chronic mild stress stimulation combined with single feed.The Anti-depression effect of ZJDZ Decoction was studied.Results： ZJDZ decoction increased the depression model of rats crossing scores and rearing scores in Open-Field significantly（P0.05）.It also improved sucrose solution intake（P0.05）.Conclusions： ZJDZ decoction has the anti-depression effect in the depression model of rat.
出处
《中国临床医学》
2011年第1期114-116,共3页
Chinese Journal of Clinical Medicine
关键词
抑郁症
中医药
动物模型
实验
Depression
Chinese traditional medicine
Animal model
Experimental study
