痛风患者血脂水平分析

Analysis of Plasma Lipids Levels in Patients with Gout

目的:分析痛风患者血脂水平特征,探讨痛风患者血脂异常的可能原因及心血管系统疾病高发生率的机制。方法:测定41例痛风患者(痛风组:急性发作期组28例,发作间歇期组13例)与40例健康体检者对照组血总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A(apoA)、载脂蛋白B(apoB)、脂蛋白(a)[Lp(a)]、氧化低密度脂蛋白(ox-LDL)和超敏C-反应蛋白(hs-CRP)浓度,并分析hs-CRP水平与血脂浓度的相关性。结果:与对照组相比,痛风组血浆中TC、LDL-C、apoB、Lp(a)和ox-LDL浓度均显著增高(P<0.05);痛风急性发作期患者hs-CRP浓度显著高于对照组(P<0.01),HDL-C浓度则显著低于对照组和痛风缓解期组(P<0.05);痛风急性发作期患者HDL-C浓度与hs-CRP呈显著负相关(r=-0.452,P<0.05)。结论:痛风患者体内致动脉粥样硬化性血脂谱特征的血脂发生显著变化,急性发作期患者血脂谱的变化可能与体内炎性反应及氧化应激有关。

Objective：To investigate plasma levels of lipids in patients with gout,then explore the mechanisms about alterations in lipids levels and high risk for cardiovascular diseases in patients with gout.Methods：A total of 41 male patients with gout（gout group;28 in acute episode phase group;13 in intermittent phase group） and 40 healthy controls（control group） were enrolled in this study.Levels of total cholestrol（TC）,triglyceride（TG）,high density lipoprotein cholestrol（HDL-C）,low density lipoprotein cholestrol（LDL-C）,apolipoprotein A（apoA）,apolipoprotein B（apoB）,lipoprotein（a） ,Oxidized low density lipoprotein（ox-LDL） and high sensitivity C-reactive protein（hs-CRP） were measured in both groups,the relationships between hs-CRP and lipids level were also explored.Results：The plasma levels of TC,LDL-C,apo-B,Lp（a） and ox-LDL in patients group were significantly higher than control group（all P0.05）;The levels of hs-CRP in acute episode phase gout were significantly higher than control group（P0.01）;In contrast,the levels of HDL-C in acute episode phase group was significant lower than control group and intermittent phase group（both P0.05）;Correlation analysis indicated that HDL-C was negatively correlated with hs-CRP activities in acute episode phase group（r=-0.452,P0.05）.Conclusions：Plasma atherogenic lipid profile is changed in patients with gout.The alterations of plasma lipids may be associated with inflammation and oxidative stress in acute episode phase gout.