摘要
目的研究2种室温离子液体三溴化1丁-基-3甲-基吡啶([BMPy]Br3)和三溴化1丁-基-3甲-基咪唑([Bmin]Br3)分别与6-甲氧基-2乙-酰基萘、4甲-基苯乙酮、4乙-基苯乙酮、2,4二-氯苯戊酮、2羟-基苯丙酮、3-硝基苯乙酮、2,4二-氯-5氟-苯乙酮、3-溴-4羟-基苯丙酮、2氯--4-(4氯-苯氧基)苯乙酮、4-苄氧基苯戊酮的α-溴化反应。方法在无溶剂、室温条件下离子液体与芳基烷基酮反应,柱层析分离产品,离子液体回收重复使用。结果顺利制备得到10个α-溴代芳基烷基酮。结论 [BMPy]Br3和[Bmin]Br3作为溴化剂选择性好,反应条件温和,收率高,操作简便,环境友好。
Objective To investigate the selective α-monobromination of 1-(6-methoxynaphthalen-2-yl) ethanone, 1-( p-tolyI ) ethanone, 1-( 4-ethylphenyl ) ethanone, 1-( 2,4-dichlorophenyl ) pentan-l-one, 1-( 2- hydroxylphenyl) propan-1 -one, 1 - ( 3-nitrophenyl ) ethanone, 1 - ( 2,4-diehloro-5-fluorophenyl ) ethanone, 1 - ( 3- bromo-4-hydroxyphenyl) propan-1 -one, 1 - [ ( 2-chloro-4- (4-chlorophenoxy) phenyl
ethanone, 1 - [ ( 4- ( benzylo- xy) phenyl] pentan-l-one with [ BMPy] Br3 and [ Bmim] Br3. Methods The ionic liquids reacted with alkylaryl ketones in room temperature under solvent-free conditions, the products was separated by column chromatography, and the ionic liquid was recycled and reused. Results Ten α-bromo-alkylaryl ketones were obtained in good yields and highly selective. Conclusion [ BMPy ] Br3 and [ Bmim ] Br3 as bromine sources proves to be a highly efficient, simple, regioseleetive reagent for electrophilic bromination of various alkylaryl ketones.
出处
《广东药学院学报》
CAS
2011年第1期23-26,共4页
Academic Journal of Guangdong College of Pharmacy
基金
广东省自然科学基金博士启动项目(10451022401005172)
关键词
室温离子液体
溴化反应
芳基烷基酮
room temperature ionic liquids
bromination
alkylaryl ketones