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固体自乳化释药系统的研究进展 被引量：1

Development of solid self-emulsifying drug delivery systems
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摘要 固体自乳化释药系统可以提高难溶性药物的溶出度和生物利用度,具有巨大的发展潜力及应用前景。本文综述固体自乳化释药系统的特点、辅料、制备方法及在新剂型中的应用。 The characterization, excipients,preparation techniques and application in new formulations of solid self-emulsifying drug delivery systems（S-SEDDS） are expatiated according to the recent research of S-SEDDS. The dissolution and the bioavailability of water - insoluble drugs can be improved by the utilization of S- SEDDS, therefore a promising application prospect of S-SEDDS can be expected in the field of medicine.
作者 叶珍珍 张建 廖华卫 崔升淼
机构地区 广东药学院中药学院
出处 《广东药学院学报》 CAS 2011年第1期108-110,F0003,共4页 Academic Journal of Guangdong College of Pharmacy
基金 广东省科技计划项目(2007B060401058) 广东省中医药局建设中医药强省科研项目(2008172)
关键词 固体自乳化释药系统 辅料 制备 应用 solid self-emulsifying delivery, systems excipients preparation application
分类号 R944.9 [医药卫生—药剂学]
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参考文献27

  • 1KANG B K, LEE J S,JEONG S K,et al. Development of self- microemulsifying drug delivery system (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs [ J ]. Ira J Pharm,2004,274( 1 -2) :65 -73.
  • 2TANG Bo, CHENG Gang, GU .lian-chun, et al. Development of solid self-microemulsifying drug delivery systems: preparation techniques and dosage forms [ J ]. Dntg Discovery Today, 2008, 13(14) :606 -612.
  • 3KATNENI K, CHARMAN S A, PORTER C J. Impact of cremophor-EL and polysorbate-80 on digoxin permeability across rat jejunum: delineation of thermodynamic and transporter related events using the reciprocal permeability approach [ J ]. J Pharm Sci ,2007,96(2 ) :280 - 293.
  • 4SHEN Q, LIN Y, HANDA T, et al. Modulation of intestinal Pglycoprotein function by polyethylene glycols and their derivatives by in vitro transport and in situ absorption studies [J]. Ink J Pharm,2006,313( 1 -2) :49-56.
  • 5KALE A A, PATRAVALE V B. Design and evaluation of self- emulsifying drug delivery systems (SEDDS) of nimodipine[ J ]. AAPS Pharm Sci Tech,2008,9( 1 ) :191 -196.
  • 6BA1,AKRISHNAN P, I,EE B J, OH D H,et al. Enhanced oral bioavailability of dexibuprofen by a novel solid self-emulsifying drug delivery system (SEDDS) [ J ]. Eur J Pharm Biopharm, 2009,72(3) :539 - 545.
  • 7BUGGINS T R, DICKINSON P A, TAYLOR G. The effects of pharmaceutical excipients on drug disposition [ J ]. Adv Drug Deliv Ret;,2007,59( 15 ) :1482 - 1503.
  • 8POUTON C W, PORTER C J. Formulation of lipid-based delivery systems for oral administration: Materials, methods and strategies [ J ]. Adv Drug Deliv Rev,2008,60 ( 6 ) :625 - 637.
  • 9BRAVO GONZAIEZ R C, HUWYLER J, BOESS F,et al. in vitro investigation on the impact of the surface-active excipients Cremophor EL,Tween 80 and Solutol HS 15 on the metabolism of midazolam [ J ]. Biopharm Drug Dispos ,2004,25 ( 1 ) :37 -49.
  • 10FOGER F, HOYER H, KAFEDJIISKI K, et al. in vivo comparison of various polymeric and low molecular mass inhibitors of intestinal P-glycoprotein [ J ]. Biomaterials, 2006, 27 ( 34 ) :5855 - 5860.

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广东药学院学报
2011年 第1期

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