疫苗生产的新途径——转基因植物

Vaccine production in transgenic plants

与发酵生产方式相比，转基因植物疫苗生产技术具有高效、经济和简便等特点。植物表达系统生产外源蛋白一般采用两种方式：（１）编码外源抗原基因与植物基因组稳定整合；（２）利用植物病毒载体，使外源蛋白在植物细胞中瞬时表达。植物系统生产的抗原疫苗可保持自然免疫原性质，口服后能够诱发体液和粘膜免疫反应。

Transgenic plants as vaccine production systems represent an economical, simple andhighly effective alternative to fermentation-based production systems. There are two differentstrategies for transgene expression in plants. (1) Stable genomic integration using genes encodingforeign antigens. (2) Transient expression using viral vectors. The vaccines produced by transgenicplants retain native immunongenic properties. The edible vaccines' can stimulate humoral andmucosal immunonresponses.