Toll信号通路在呼吸机相关性肺损伤中的作用

Toll Signaling Pathway in Ventilator-induced Lung Injury

呼吸机相关性肺损伤(Ventilator-associated lung injury,VILI)是机械通气引起的严重并发症,目前临床上仍然缺乏完全有效的治疗策略。随着对VILI发病机制的不断深入研究,Toll样受体依赖的信号转导通路被认为参与了VILI的发生发展。Toll样受体识别相关配体后,通过启动细胞内外信号级联反应,介导肺部炎性因子的释放及释放后的病理生理改变。深入研究Toll样受体在VILI中的作用,可为临床提供参考。

Ventilator-induced lung injury（VILI）is a serious complication caused by mechanical ventilation,and there is no effective treatment for the VILI currently.With the deepening of research on the pathogenesis of VILI,Toll signaling pathway is considered involving in the pathogenesis of VILI.TLRs recognize related ligands,then initiate the signaling cascade of cells,after that,release inflammatory factors in the lungs and change the pathophysiological progress.Continuous research on the role of TLRs may provide a new way of prevention and treatment of VILI.