骨桥蛋白与卵巢癌诊断的研究进展

An Overview of the Osteopontin as a Diagnostic Marker for Ovarian Cancer

骨桥蛋白(OPN)是一种磷酸化糖蛋白,不仅在卵巢癌及卵巢交界性恶性肿瘤组织中的表达高于在良性肿瘤和正常卵巢上皮组织,而且晚期卵巢癌组织中的表达也明显高于早期癌,在有癌转移的淋巴结中同样高表达。OPN的血清学检查不仅可以用于区别健康人群和卵巢癌患者,还可用于区分卵巢癌和卵巢良性肿瘤。OPN与其他肿瘤标志物联合检测时可以提高卵巢癌的检出率。本文同时还简述了OPN与其他妇科疾病的关系。

Osteopontin（OPN）is a kind of glyco-phosphoprotein.Immunolocalization of osteopontin showed that the expression levels of OPN in tissue samples from ovarian cancer and borderline ovarian tumors were higher than those from benign tumors and healthy ovarian epithelium.And it is showed that the levels of osteopontin in ovarian cancer of advanced stage were higher than those of early stage.The expression level of the osteopontin is high in lymph node with metastasis of cancer,too.Osteopontin levels in plasma of ovarian cancer were higher than those of benign ovarian disease and the health,which could distinguish the ovarian from the benign ovarian disease and the health.The combination of OPN and other tumor makers improved the diagnostic effects of ovarian cancer significantly.The article summarized the relationship between OPN and some other gynecological diseases.