慢性肝病患者微量元素的研究

Study on microelements in patients with chronic liver diseases

目的研究不同慢性肝病患者微量元素钙、镁、锌、铜、铁的变化及相互之间得到联系,探讨微量元素在慢性肝病治疗中的意义。方法采用原子吸收法检测慢性肝病患者血清微量元素含量。结果与正常对照组比较,慢性肝炎组、肝炎后肝硬化组患者血清中钙、镁、锌均明显降低(P<0.01),慢性肝炎组血清铁、铜增高,差异有统计学意义(P<0.05);而肝炎后肝硬化组血清铁降低,血清铜增高,差异均有统计学意义(P<0.05)。与慢性病毒性肝炎组比较,肝炎后肝硬化组血清中钙、镁、锌、铁均降低,差异有统计学意义(P<0.01),而血清铜增高,差异亦有统计学意义(P<0.05)。而正常对照组、肝炎组和肝硬化组内血清钙和镁含量之间存在相关性(P<0.05)。结论慢性肝病患者血清中微量元素钙、镁、锌、铜、铁含量均明显异常,通过对这些微量元素的代谢进行分析,对慢性肝病的治疗可能具有重要临床意义。

Objective To study the changes and correlation of calcium,magnesium,zinc,copper and iron in patients with various chronic liver diseases,and to explore the therapeutic significance of microelements for patients with chronic liver diseases.Methods The levels of microelements were measured by atomic absorption spectrometry.Results In comparison with normal controls,the serum levels of calcium,magnesium and zinc were decreased in patients with chronic hepatitis and cirrhosis（P〈0.01）,the serum levels of copper and iron were increased in patients with chronic hepatitis（P〈0.05）,the liver cirrhosis group decreased serum iron,serum copper increased（P〈0.05）.In comparison with cases of chronic hepatitis,serum levels of calcium,magnesium,zinc and iron in patients with cirrhosis were decreased（P〈0.01）,but their serum level of copper was elevated（P〈0.05）.There was correlation in serum levels of calcium and magnesium among normal controls and patients with chronic hepatitis and cirrhosis（P〈0.05）.Conclusion The serum levels of calcium,magnesium and zinc in patients with chronic hepatitis and cirrhosis are abnormal,and they may be important in clinical significance of treatment for patients with various chronic liver diseases.