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抗HIV药物临床耐药研究进展 被引量：5

Progress in researches on clinical resistance of anti-HIV drugs
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摘要 高效抗反转录病毒治疗(HAART)开展以来,控制了艾滋病病毒/艾滋病(HIV/AIDS)及相关疾病的进程,延长了患者的生存时间。然而由于HIV有高度的遗传变异性,同时在药物选择压力的作用下,HIV可逐渐对一种或几种药物产生耐药。随着HAART时间的延长及治疗人数的增多,HAART在目前及今后的治疗中面临HIV耐药的考验。对HIV临床耐药进行总结分析,有利于合理开展HAART治疗并减少耐药病毒株的出现及传播。 With expanding highly active antiretroviral therapy （HAART）, the process of HIV/AIDS and related diseases, has been under control and the survival of the patients has been prolonged. However, due to highly mutated RNA-viral H1V and under the drug selective pressure, resistance to one or several drugs may evolve. HAART is faced with a challenge in the future owing to the increasing number of patients receiving HAART in a longer period of time. An analysis of clinical resistance of anti HIV drugs will help to rationally expand HAART and reduce the emerging and spread of drug resistant viral strains .
作者 毛霖 汪习成
机构地区 云南省传染病专科医院
出处 《中国艾滋病性病》 CAS 2011年第1期92-95,共4页 Chinese Journal of Aids & STD
基金 "十一五"国家科技重大专项(2009ZX10004-902)
关键词 艾滋病 高效抗反转录病毒治疗 耐药 AIDS HAART Drug resistance
分类号 R512.91 [医药卫生—内科学]
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参考文献22

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共引文献17

同被引文献56

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引证文献5

二级引证文献37

中国艾滋病性病
2011年 第1期

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