DNA聚合酶Polι的研究进展

Progress in DNA polymerase iota

Y家族DNA聚合酶是一种跨损伤复制酶,即能以损伤的DNA为模板进行复制。Y家族DNA聚合酶广泛分布生物界,人类细胞中Y家族DNA聚合酶至少包括Rev1、Polκ、Polι、Polη四种,Polι在以DNA为模板进行复制时错配率很高而不同于其他跨损伤DNA聚合酶,Polι是目前发现的所有DNA聚合酶中保真性最低的DNA聚合酶。很高的错配率导致很高的突变率,最后基因的突变导致癌症的发生,因此Polι在各个国家被广泛的研究,并且对Polι的各个不同的特性进行了研究,取得了一系列成果,现对Polι的研究进展予以综述,并展望了未来的研究趋势。

Y-family DNA polymerases are one kind of polymerases which replicating damaged template.Y-family DNA poly-merases are widely distributed among the three kingdoms of life.Human cells contain at least four：i.e,Rev1 Polκ Polι and Polη,and Polι is different from the other three DNA polymerases of bypassing damaged template for the rate of mismatching when it replicates DNA is very high.DNA polymerase iota has the lowest fidelity in all of DNA polymerases so far.The high rate of mismatching result in high rate of mutation,Even mismatching was reported to be related to the occurrence of cancer Therefore the DNA polymerase iota were researched worldwide,for its polymerase from different properties,and gain a series of outcomes.In addition,the prospect of future re-search is addressed.