摘要
E-钙粘素介导上皮细胞的同型相互作用,在形态发生、信号转导、细胞极性及组织细胞完整性的维持中起着重要作用。E-钙粘素介导的黏附功能紊乱将导致细胞间粘连松散,与肿瘤侵袭转移密切相关,与肾脏疾病的相关性也越来越受到重视。其相关蛋白在疾病的发生、发展过程中,也起了不可忽视的作用,现就E-钙粘素及相关蛋白的研究进展做一综述。
E-cadherin can mediate the homeotype interaction in epithelial cells.It plays an important role in morphogenetic,cell signaling and trafficking,epithelial polarity and matain structual integrity.It is because of adhersion dysfuction by E-cadherin mediated that cell to cell cohesion loosing,which is closely relevated to tumors invasion and metastasis.And in present it is increasingly to pay close attention to its correlation with kidney diaease.And its associated proteins also play an important role during the happening and developing of the disease.This paper reviewed progress of E-cadherin and its associated proteins.
出处
《现代生物医学进展》
CAS
2011年第2期375-377,共3页
Progress in Modern Biomedicine
关键词
E-钙粘素
相关蛋白
肿瘤
肾病
E-cadherin
Associated protein
Tumor
Nephropathy
