视黄醇结合蛋白4与2型糖尿病微血管病变的研究进展

Relationship between Retinol Binding Protein 4 and Microvascular Complication of Type2 Diabetes Mellitus

视黄醇结合蛋白4(Retinolbindingprotein4,RBP4)是一种分泌型视黄醇结合蛋白,主要由肝脏合成,在协助视黄醇发挥生理功能中起着重要的作用。近年研究发现,RBP4是一种新的循环性脂肪因子,亦能由脂肪组织特异性分泌,它不仅能够抑制肌肉组织中的胰岛素信号通路,而且能够促进糖异生,增加肝糖输出,从而导致胰岛素抵抗的发生,增加糖尿病的发病风险。目前RBP4与2型糖尿病(Type2diabetes mellitus,T2DM)关系逐渐受到人们的重视,本文就RBP4的生理功能、RBP4与T2DM微血管病变的研究进展作一综述。

Retinol binding protein 4（RBP4） is a kind of secretion of retinol binding protein,mainly synthesized by the liver.It plays an important role in assisting the physiological function of retinol.In recent years,the studies have found RBP4 is a new kind of cir-culating adipocytokine,and can be specific secreted by the adipose tissues.It can not only inhibit the insulin signaling pathway of muscle tissue,but also promote gluconeogenesis and increase the glycogen output of liver,thus lead to insulin resistance,increases the morbidity of diabetes.Currently,the relationship between RBP4 and type 2 diabetes mellitus（T2DM）has been paid gradually attention by many scholars.This article describes the function of RBP4,review the relationship between RBP4 and micro-vascular complication with T2DM.