冠心病稳定型心绞痛患者基质金属蛋白酶-9、可溶性E选择素及组织型纤溶酶原激活物抑制剂-1表达变化

Expression changes of matrix metalloproteinase-9,solubleE-selectin,tissue plasminogen activator inhibitor-1 in patients with stable angina pectoris

目的:探讨冠心病稳定型心绞痛(SAP)患者基质金属蛋白酶-9(MMP-9)、可溶性E选择素(sE-se-lectin)及组织型纤溶酶原激活物抑制剂-1(tPAI-1)表达变化。方法:采用液相芯片分析系统同步检测206例经冠状动脉造影证实的SAP患者及28例健康对照者血清MMP-9、sE-selectin及tPAI-1表达程度,并比较3者之间及与冠状动脉病变程度的相关性。结果:SAP患者血清MMP-9、tPAI-1及sE-selectin表达程度较对照者升高,其中前2项差异有统计学意义(P<0.01);3者变化呈显著正相关(P<0.01)。结论:SAP患者冠状动脉斑块具有一定程度炎性反应,血液呈现高凝状态,故具有一定不稳定性。炎性因子和纤溶系统标记物可能成为判定SAP患者危险分层的依据。

Objective：To explore the expression changes of matrix metalloproteinase-9（MMP-9）,soluble E-selectin（sE-Selectin）,tissue plasminogen activator inhibitor-1（tPAI-1） in patients with stable angina pectoris（SAP）.Method：The expressions of MMP-9,sE-Selectin and tPAI-1 in 206 patients with SAP measured by coronary angiography and 28 cases of healthy people were detected by liquid chip analysis system.The pairwise correlations among the parameters of MMP-9,sE-Selectin,tPAI-1 and the lesion of coronary artery were analyzed.Result：The expressions of MMP-9,tPAI-1 and sE-Selectin in patients with SAP were all obviously higher than those in healthy people,with a significant difference in MMP-9 or tPAI-1（P0.01,respectively） and a positive corelation between all of these three parameters（P0.01）.Conclusion：There is a certain degree of inflammatory reaction in coronary plaques in patients with SAP,in which the blood shows hypercoagulable state.Therefore,coronary plaques have instability.Inflammatory factor and the marker of fibrinolytic system provide a basis for risk stratification of SAP.