原田病药物治疗后吲哚青绿眼底血管造影观察

Indocyanine Green Angiography findings in Harada, s disease after drug treatment

目的探讨利用吲哚青绿血管造影检查作为原田（Harada）病临床观察指标的意义。方法对经药物治疗后19例（38只眼）原田病患者同时行荧光素眼底血管造影（fundus fluorescein angiography，FFA）及吲哚青绿血管造影（indocyanine green angiography，ICGA）检查资料进行分析。结果FFA检查发现有4例（8只眼）视盘轻度染色，视网膜未发现异常改变；ICGA早期及中期无异常表现，但后期8只眼（包括FFA中视盘染色的4只眼）在中周及后极部出现了点状或斑片状弱荧光；3例6只眼FFA及眼底正常，在ICGA后期后极部出现了斑点状弱荧光；24只眼脉络膜大、中血管影像减少，其中12只眼dalen—fuchs结节着色。结论ICGA可较好提供原田病的脉络膜循环损害的信息，并在评价疗效上有意义。

Objective To investigate the clinical value of indocyanine green angiography （ICGA） in patients with Harada disease. Methods Fundus fluorescein angiography （FFA） and indocyanine green angiography （ICGA） were used for comparative analyses in 26 cases （52 eyes） of Harada disease after treatment. Besuits Mild dyeing in disk was found only in 4 cases （8 eyes）, and the others were not found any abnormal in FFA. There were no any abnormal found in early period and middle period of ICGA, but of 8 eyes （include 4 eyes of dyeing in disk in FFA） multifocal lower fluorescence were found in the mid-periphery and posterior pole of the fundus in＇the late phase, Of 3 cases （6 eyes） were normal in FFA, however multifocal lower fluorescence were found in the posterior pole of the fimdus in the late phase of ICGA. Of 24 eyes were found decreased fluorescence in large and middle choroidal vessel, and 12 eyes of Dalen-Fuchs were colored. Conclusions ICGA may assist in providing valuable information on choroidal circulation of Harada disease and be useful in evaluating the curative effects.