血管内皮生长因子在原发性肝癌组织中的表达及临床意义

Expression and clinical significance of VEGF in tissue of primary hepatocellular carcinoma

目的:探讨血管内皮生长因子(VEGF)在原发性肝癌组织中的表达及其与肿癌的浸润转移的关系。方法:采用SP免疫组化法,检测60例原发性肝癌标本、30例癌旁组织和30例正常组织中VEGF的表达。结果:肝癌组的VEGF阳性表达率为68.3%,显著高于癌旁组(40.0%)和正常对照组(33.3%),有统计学差异(P<0.05);包膜不完整组织中VEGF阳性表达为92.9%,显著高于包膜完整组织(P<0.05);远处转移组织中VEGF阳性表达率为96.6%,显著高于无转移组织(P<0.05);而VEGF阳性表达在不同的TNM分期之间、肿瘤分化程度之间以及不同的病灶大小之间差异无统计学意义(P>0.05)。结论:VEGF在原发性肝癌组织中呈高表达,VEGF表达与肿瘤包膜有无和是否发生远处转移有关,VEGF在肝癌血管生成、生长及转移中起重要作用。

AIM： To study the expression and clinical significance of vaseular endothelial growth factor（VEGF） in tissue of primary hepatocellular carcinoma （PHC） and effects on tumor invasion and metastasis. METHODS： The VEGF expression from 60 cases of PHC tissues, 30 cases of adjacent tissues and 30 cases of normal tissue were detected by SP immunohistochemical method. RESULTS： The VEGF positive rate of the PHC group was 68.3%, the adjacent tissues group was 40.0%, and the normal tissue group was 33.3%, compared the different was significant （ P 〈 0.0.5） ; The VEGF positive rate of the incomplete capsule tissues was 92.9%, which was significantly higher than the complete capsule tissues （ P 〈 0.05） ; and The VEGF positive rate was no significantly different among the different TNM stage, different degree of tumor differentiation and different lesion size（ P 〉 0.05）. CONCLUSION： The VEGF has high expression in PHC tissues. The VEGF expression has close relation with the whether tumor capsule and distant metastasis. The VEGF plays an important role anglogenesis of PHC, growth and metastasis.