浅析阿司匹林抵抗产生的机理与防治措施

Brief Analysis on the Generation Mechanism of Aspirin Resistance and Control Measures

阿司匹林是使用最多、使用时间长的解热、镇痛和消炎药物,能抑制体温调节中枢的前列腺素合成酶,使前列腺素(pge1)合成、释放减少,从而恢复体温中枢的正常反应性,使外周血管扩张并排汗,使体温恢复正常。本品尚具抗炎、抗风湿作用,并促进人体内所合成的尿酸的排泄,对抗血小板的聚集。适用于解热,减轻中度疼痛如关节炎、神经痛、肌肉痛、头痛、偏头痛、痛经、牙痛、咽喉痛、感冒及流感症状。但是临床上有5%～60%的患者虽常规服用阿司匹林,却不能有效地抑制血小板的活性,这种现象被称为阿司匹林抵抗。本文结合多年经验,以研究阿司匹林动力学为基础,探讨了阿司匹林抵抗机理及其防治措施。

Aspirin is the most used medicine with long time antipyretic,analgesic and anti-inflammatory,it can inhibit prostaglandin synthase of body temperature regulation center,making prostaglandin（pge1） synthesis and release decrease,thereby restoring the body normal reaction of temperature,so that achieving peripheral vasodilatation and perspiration with body temperature returning to normal.This product still has the function of anti-inflammatory,anti-rheumatic,and promoting the body＇s excretion of uric acid synthesized against platelet aggregation,which is suitable for alleviating fever and moderate pain such as arthritis,neuralgia,muscle pain,headache,migraine,dysmenorrhea,toothache,sore throat,colds and flu symptoms.But despite regular taking aspirin for the clinical 5% to 60% of patients,it can not effectively inhibit platelet activity,a phenomenon known as aspirin resistance.Combined with years of experience and based on the pharmacokinetics of aspirin,the resistance mechanism of aspirin and its control measures are discussed.