摘要
目的探讨人类白细胞抗原(HLA)-DQB1基因多态性与我国南方汉族人群多发性硬化(MS)的相关性。方法采用基因测序的方法(SBT)对42例南方汉族MS患者及48名健康对照者进行HLA-DQB1等位基因的检测,并比较MS组与健康对照组之间等位基因型频率的差异。结果共检测到15种HLA-DQB1等位基因片段,其中DQB1*0502等位基因频率MS组(35.7%)显著高于健康对照组(8.9%)(P=0.0018,Pc=0.027,OR=4.29);DQB1*0303等位基因频率MS组(19.0%)低于健康对照组(39.6%)(P=0.04,OR=0.48),但差异经校正后无统计学意义。HLA-DQB1*0601和DQB1*0602等位基因频率在MS组患者与健康对照组之间差异无统计学意义。结论我国南方汉族人群MS与HLA-DQB1*0502等位基因有关,而与HLA-DQB1*0601和DQB1*0602等位基因无关。
Objective To approach the association between human leucocyte antigen(HLA)-DQB1 allele gene polymorphism and multiple sclerosis(MS) in Han population from southern area of China.Methods The HLA-DQB1 genotypes of the 42 Han patients with MS(MS group) and 48 healthy controls(healthy control group) all of them from southern area of china were determined by sequencing-based typing(SBT) method.The frequencies of the DQB1 alleles were compared between the two groups.Results A total of 15 DQB1 allele genes were identified.The frequency of the DQB1*0502 allele gene in the MS group(35.7%) was significantly higher than that in the healthy control group(8.9%)(P=0.0018,Pc=0.027,OR=4.29).The frequency of the DQB1*0303 allele gene in the MS group(19.0%) was lower than that in the healthy control group(39.6%)(P=0.04,OR=0.48),but the difference was no statistical significance since corrected.In addition,the freguencies of HLA-DQB1*0601 and DQB1*0602 allele genes were no significantly difference between the MS group and health control group.Conclusion MS in Han population from southern area of China is associated with HLA-DQB1*0502 allele gene,but not with the DQB1*0301 and DQB1*0602 allele genes.
出处
《临床神经病学杂志》
CAS
北大核心
2011年第1期11-13,共3页
Journal of Clinical Neurology
基金
江西省自然科学基金资助项目(2008GZY0085)
江西省卫生厅科研基金资助项目(0301095)
关键词
多发性硬化
基因多态性
中国汉族人群
人类白细胞抗原-DQB1
multiple sclerosis
genetic polymorphism
Han population from southern area of China
human leucocyte antigen-DQB1