参芎注射液对急性脑梗死患者血小板-白细胞聚集体的影响

Effects of Shenxiong injection on platelet-leukocyte aggregation in patients with acute cerebral infarction

目的观察参芎注射液对急性脑梗死(ACI)患者血小板-白细胞聚集体(PLA)的影响。方法将51例AC I患者随机分为阿司匹林组和阿司匹林+参芎注射液组,检测两组治疗前后PLA、血小板中性粒细胞聚集体(PNA)、血小板淋巴细胞聚集体(PLyA)和血小板单核细胞聚集体(PMA)的水平,以及血小板聚集率(PAR)、C反应蛋白(CRP)、血白细胞、血小板、血脂、血糖和纤维蛋白原(Fg)水平、美国国立卫生研究院卒中量表(NIHSS)评分的变化。结果阿司匹林组:PLA、PNA、PLyA以及CRP均有下降趋势,但与治疗前比较差异无统计学意义,而PMA、PAR以及NIHSS评分较治疗前明显降低(均P<0.05)。阿司匹林+参芎注射液组:PLA、PMA、PAR、CRP以及NIHSS评分较治疗前明显下降(均P<0.05),其中PMA和PAR下降较阿司匹林组更为明显(均P<0.05),而PNA、PLyA有下降趋势但与治疗前差异比较无统计学意义。两组治疗前后白细胞、血小板、血脂、血糖和Fg水平的差异均无统计学意义。结论参芎注射液具有协同抗血小板活化与聚集,抑制PLA,特别是PMA形成的作用,此外还具有一定的抗炎功效。

Objective To observe the effects of Shenxiong injection on leukocyte-platelet aggregations（PLA） in patients with acute cerebral infarction（ACI）.Methods 51 patients with ACI were randomly divided into aspirin group and aspirin＋Shenxiong injection group.The levels of PLA,platelet neutrophil aggregates（PNA）,platelet lymphocyte aggregates（PLyA）,platelet monocyte aggregates（PMA）,C-reactive protein（CRP）,white blood cells,blood platelet,blood lipids,blood glucose,fibrinogen（Fg） and NIHSS score in two groups were detected before and after treatment.Results In aspirin group,the levels of PLA,PNA,PMA,PLyA,and CRP after treatment had decreased tendency with no statistical difference compared with those in pretherapy,and the levels of PMA,PAR and NIHSS score were significantly decreased（all P0.05）.In aspirin＋Shenxiong injection group,the levels of PLA,PMA,PAR,CRP and NIHSS score were significantly decreased after treatment（all P0.05）,and the levels of PMA and PAR were decreased sharperly than those in aspirin group（all P0.05）,but the levels of PNA and PlyA were decreased without statistical difference compared with those in pretherapy.There was no statistical difference of the levels of white blood cells,blood platelets,blood lipids,blood glucose and Fg between pre and post treatment.Conclusions Shenxiong injection has synergia anti-platelet activation and aggregation through restraining PLA,especially the formation of PMA.In addition,it also has some anti-inflammatory effect.