摘要
目的观察拉莫三嗪对癫癎患者血清甲状腺激素水平的影响。方法用化学发光分析法检测51例癫癎患者(癫癎组)拉莫三嗪治疗前及治疗后3个月、6个月、12个月的血清甲状腺激素水平,并与43名正常对照者进行比较。结果癫癎组患者治疗前血清甲状腺激素水平与正常对照组比较,差异均无统计学意义;拉莫三嗪治疗后3个月、6个月、12个月的甲状腺激素水平与治疗前及正常对照组比较,差异亦均无统计学意义。结论拉莫三嗪对癫癎患者的甲状腺激素水平没有明显影响,安全性好。
Objective To observe the effects of Lamotrigine（LTG） on serum thyroid hormone levels in patients with epilepsy.Methods Serum thyroid hormone levels were measured by chemoluminescence technique in 51 epileptic patients（epileptic group） before and 3,6 and 12 months after LTG treatment,and the results were compared with 43 normal controls.Results There was no significant difference of serum thyroid hormone levels between epileptic group before treatment and normal control group.The thyroid hormone levels in patients at 3,6 and 12 months after LTG treatment were no significantly different compared with before treatment and normal controls.Conclusion LTG has no obvious effects on serum thyroid hormone levels in patients with epilepsy,which indicates that LTG is safe to thyroid function.
出处
《临床神经病学杂志》
CAS
北大核心
2011年第1期65-67,共3页
Journal of Clinical Neurology
