老年亚临床型甲状腺功能减退患者认知功能障碍的特点

Features of cognitive function impairment in old patients with subclinical hypothyroidism

目的观察老年亚临床型甲状腺功能减退（SHT）患者认知功能障碍的特点。方法对15例血清促甲状腺激素（TSH）在5~10m IU/L之间的老年SHT患者进行蒙特利尔认知评估（MoCA）量表、词语和无意义图形再认,以及瑞文标准推理测验,并与对照组进行比较。结果 SHT组MoCA总分及词语延迟回忆、命名、词语和无意义图形再认的分数均较对照组降低,差异有统计学意义（均P〈0.05）。结论老年SHT患者认知功能损害主要表现为记忆障碍,具有选择性;是否需左旋甲状腺素治疗应个体化。

Objective To observe the features of cognitive function impairment in old patients with subclinical hypothyroidism（SHT）.Methods Fifteen old patients with SHT and the serum thyroid stimulating hormone（TSH） concentration was between 5 to 10 mIU/L underwent the tests of Montreal Cognitive Assessment（MoCA）,recognition of computerized words and non-meaning delineation and Raven＇s Standard Progressive Matrices.The results were compared with the control group.Results SHT group manifested poorly in total scores of MoCA and words delayed recall,nomination as well as recognition of words and non-meaning figures in comparison with control group,the difference of scores were statistically significant（all P0.05）.Conclusions Cognitive dysfunction in old patients with SHT mainly lies in memory,which indicates the selectivity of the cognitive impairment.The individualized decision for therapy should be made.