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蛋白激酶蛋白家族的功能研究进展 被引量：7

Advances in the function of protein kinase D family
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摘要 蛋白激酶D(protein kinase D,PKD)属丝氨酸/苏氨酸(serine/threonine,Ser/Thr)蛋白质家族,主要包括3个成员:PKD1/PKCμ、PKD2、PKD3/PKCν。其结构相对保守,均具有相似的调节结构域和激酶结构域。近年来的研究表明PKD家族蛋白参与细胞生长、增殖、迁移、分化、凋亡,高尔基体的组织和重建,免疫应答,内分泌调节、增强心肌收缩力等多种生理功能。 Protein kinase D（PKD） is a kind of Ser/Thr protein kinases including three members：PKD1/PKCμ,PKD2,PKD3/PKC.All of them have conserved structures and similar regular domains.Recently many investigations have found that PKDs contribute to many cellucar biological functions such as cell survival,migration,differentiation,apoptosis,organization and regeneration of Golgi＇s apparatus,immune responses,regulation of endocrine secretion and myocardial contractility.
作者 刘思旸 邹志鹏 郦俊 邓凡
机构地区 南方医科大学第一临床医学院细胞生物学教研室
出处 《医学研究生学报》 CAS 2011年第2期208-211,共4页 Journal of Medical Postgraduates
基金 国家自然科学基金(30973014)
关键词 蛋白激酶D 信号转导 Protein kinases D Signal transduction
分类号 Q555.7 [生物学—生物化学]
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参考文献22

  • 1Wang QJ.PKD at the crossroads of DAG and PKC signaling[J].Trends Pharmacol Sci,2006,27(6):317-323.
  • 2Leyla Y.Protein kinase D regulates L-type Ca2+ current in cardiac ventricular myocytes[J].Biophys J,2009,96(3suppl):512a.
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  • 5Geng J,Zhao Z,Kang W,et al.Atorvastatin reverses cardiac remodeling possibly through regulation of protein kinase D/ myocyte enhancer factor 2D activation in spontaneously hypertensive rats[J].Pharmacol Res,2010,61(1):40-47.
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  • 7Shapiro BA,Olala L,Arun SN,et al.Angiotensin II-activated protein kinase D mediates acute aldosterone secretion[J].Mol Cell Endocrinol,2010,317(1-2):99-105.
  • 8Sumara G,Formentini I,Collins S,et al.Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis[J].Cell,2009,136(2):235-248.
  • 9Li J,Chen LA,Townsend CM Jr,et al.PKD1,PKD2,and their substrate Kidins220 regulate neurotensin secretion in the BON human endocrine cell line[J].J Biol Chem,2008,283(5):2614-2621.
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二级参考文献29

共引文献15

同被引文献142

  • 1周佳雁,沈捷,马向华.胰岛素及其类似物与肿瘤相关性研究进展[J].医学研究生学报,2011,24(12):1336-1339. 被引量：7
  • 2王涤非,邱忠霞,张锦,蒋丽娟,蔡东梅,刘清利,丁梅.北方汉族2型糖尿病人胰岛素受体底物1基因多态性的研究[J].中国病理生理杂志,2005,21(4):793-796. 被引量：6
  • 3李小攀,谭晓洁,常文军,曹广文.蛋白酪氨酸磷酸酶受体D基因在肿瘤发生发展中作用的研究进展[J].肿瘤,2010,30(10):894-896. 被引量：2
  • 4Hoy AJ, Brandon AE, Turner N, et al. Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation[J]. Am J Physiol Endocrinol Metab, 2009, 297(1):E67-E75.
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  • 6Esposion DL, Li Y, Vanni C, et al. Anovel T608R mis-sense mutation in insulin receptor substrate-1 identifide ina subjectwith type 2 diabetes impairs metabolic insulin signaling[J]. J Clin Endocrinol Metab, 2003, 88(4):1468-1475.
  • 7Nawaratne R,Gray A,Jrgensen CH,et al. Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C:role of serine 24 phosphorylation[J]. Mol Endocrinol,2006, 20(8):1838-1852.
  • 8Hribal ML, Federici M, Porzio O, et al. The Gly->Arg 972 amino acid polymorphism in insulin receptor substrate-1 affects glucose metabolism in skeletal muscle cells[J]. J Clin Endoerinol Melab, 2000,85(5):2004-2013.
  • 9Bezerra RM, de Castro V, Sales T, et al. The Gly 972 Arg polymorphism in insulin receptor substrate-1 is associated with decreased birth weight in a population-based sample of Brazilian newborns[J]. Diabetes Care, 2002,25(3):550-553.
  • 10Berger D, Barroso I, Soos M, et al. Genetic variants of insulin receptor substrate-1 (IRS-1) in syndromes of severe insulin resistance. Functional analysis of Ala 513 Pro and Gly 1158 Glu IRS-1[J]. Diabet Med, 2002,19(10):804-809.

引证文献7

二级引证文献35

医学研究生学报
2011年 第2期

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