小蘖硷对严重充血性心衰的疗效及其血浆中浓度研究(英文)

A Stndy on the Clinical Effects of Berberine on Severe Congestive Heart Failure and Its Concentration in Plasma C

用高效液相色谱法研究了小蘖硷浓度对严重充血性心衰的疗效及其血浆中浓度的关系，结果表明：血浆中小蘖硷浓度大于０－１１ｍ ｇ／Ｌ 的患者（ｎ ＝ ３１ ，Ｂ 组） ，其室性早博频率及复杂性的减少和左室射血分数增加比血浆中小蘖硷浓度低于０－１１ ｍｇ／Ｌ（ｎ ＝ ２５ ，Ａ 组） 的患者更为显著。

The relationship beeween clinical effects of berberine on severe congestive heart failure and its concentration in plasma has been studied by HPLC. The decrease in frequency and complexity of VPB S and the increase in LVEF in patients with plasma berberine concentrations higher than 0.11mg/L (n=31,group B) were more significant than at concentrations lower than 0.11mg/L( n=25 ,qronp A) (p<0.01 vs p<0.05).