1型糖尿病易感基因的研究进展

Progress in Research on Susceptibility Genes of Type 1 Diabetes Mellitus

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摘要 1型糖尿病的病因和发病机制较复杂,至今仍未完全明确。近年的研究认为其发病与遗传因素密切相关。SH2B3、TC-PTP和RGS1是已经全基因组关联分析证实的有关1型糖尿病的易感基因。本文就与1型糖尿病相关的主要易感基因的研究进展作一综述。 The etiology and pathogenesis of type 1 diabetes mellitus are complex,which are unclear at present.The studies in recent years suggest that the incidence of type 1 diabetes is highly linked with genetic factors.SH2B3,TC-PTP and RGS1 are confirmed susceptibility genes of type 1 diabetes by genome wide association study.The progress in research on susceptibility genes of type 1 diabetes is reviewed in this paper.

作者李雅静郑源强张纪岩石艳春

机构地区内蒙古医学院分子生物学研究中心军事医学科学院基础研究所分子免疫学研究室

出处《中国生物制品学杂志》 CAS CSCD 2011年第2期241-244,共4页 Chinese Journal of Biologicals

基金国家973计划项目(2010 CB911904) 教育部"春晖计划"项目(Z2007-1-01004 Z2007-1-01001) 内蒙古自治区科技计划项目(20080502)

关键词 1型糖尿病易感基因全基因组关联分析 Type 1 diabetes Susceptibility gene Genome wide association study

分类号 R587.1 [医药卫生—内分泌]

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中国生物制品学杂志

2011年第2期

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1型糖尿病易感基因的研究进展

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