c-Met在乳腺癌组织中的表达及其临床价值

Expression of c-Met and its clinical significance in breast cancer

目的:探讨c-Met的表达规律,与乳腺癌术前新辅助化疗的敏感性和预后的关系。方法:采用免疫组织化学染色方法(SP法)检测147例乳腺癌组织中c-Met的表达,分析c-met的表达与各临床病理因素及术前新辅助化疗敏感性的关系;结合随访资料,分析c-Met表达对乳腺癌生存率的影响。结果:乳腺癌组织c-Met的阳性表达与组织学分级、淋巴结转移、肿瘤分期显著相关(P<0.05),与化疗敏感性及预后相关。结论:c-Met表达与乳腺癌腋窝淋巴结转移及化疗敏感性有关,可作为乳腺癌预后判断的辅助指标。

Objective To study the expression of c-Met in breast cancer,and its response to neoadjuvant chemotherapy and prognosis.Methods Immunohistochemical staining of c-Met was performed by the standard streptavidin-peroxidase（SP） technique for the paraffin section of 147 breast cancers.The relationship between the c-Met expression and the clinicopathological parameters or the results of neoadjuvant chemotherapy were analyzed.The correlation between c-Met expression and the survival rate of patients,for whom long-term follow-up data were available,was investigated.Results The expression of c-Met in breast carcinoma tissues were significantly correlated with the histologic grade,lymph nodal metastasis and tumor staging（P0.05）.It was related to neoadjuvant chemotherapy and patient survival.Conclusions The expression of c-Met in breast cancer was strongly associated with axillary lymph node metastasis and response to neoadjuvant chemotherapy.It could be used as a significant prognostic parameter of outcome in breast cancer.