摘要
以N-异丙基丙烯酰胺(NIPA)、丙烯酰胺(AM)为单体,过硫酸铵为引发剂,N,N′-亚甲基双丙烯酰胺为交联剂,采用泡沫分散聚合法制备N-异丙基丙烯酰胺与丙烯酰胺共聚物[P(NIPA-co-AM)]超大孔水凝胶,研究了丙烯酰胺、引发剂、交联剂、盐酸、碳酸氢钠用量对水凝胶溶胀、退溶胀性能的影响,通过DSC、SEM、FTIR表征材料的结构。结果表明凝胶随着AM含量的增加其相变温度(LCST)也随之提高。当AM摩尔含量为20%,引发剂的质量浓度为20 g/L,交联剂的质量浓度为3.5 g/L,盐酸的摩尔浓度为0.55 mol/L,NaHCO3的质量浓度为5.0×102g/L时,所制得凝胶具有良好的多孔结构,兼具快速的溶胀和退溶胀速率,良好的温度敏感性等特点,可适用于大分子药物的负载释放。
Poly（N-isopropylacrylamide-co-acrylic amide） [P（NIPA-co-AM）] superporous hydrogels were prepared by dispersion polymerization in foam state using N-isopropylacrylamide（NIPA） and acrylic amide（AM） as monomers,ammonium persulfate（APS） as initiator,N,N＇-Methylene-bis-acrylamide（BIS） as crosslink agent.Its swelling ratio and deswelling ratio were measured when the molar content of AM,the dosages of initiator or crosslink agent or HCI or NaHCO3 were changed.The structure of SPH was characterized by DSC,FTIR and SEM.The results show that lower critical solution temperature（LCST） of P（NIPA-co-AM） gels is improved with the increasing molar content of AM.The hydrogel prepared at condition of x（AM）=20%,ρ（APS）=20 g/L,ρ（BIS）=3.5 g/L,c（HCI）= 0.55 mol/L,ρ（NaHCO3）= 5.0×10^2 g/L,is more superporous which has higher swelling ratio and deswelling ratio,and good temperature sensitive properties,which makes it possible to load and release with macromolecular drugs.
出处
《复合材料学报》
EI
CAS
CSCD
北大核心
2011年第1期61-67,共7页
Acta Materiae Compositae Sinica
基金
福建省自然科学基金(2009J01319)
泉州市优秀人才培养专项(08A01)
泉州市科技计划重点项目(2009Z60)
关键词
泡沫分散聚合法
超大孔
快速溶胀
温敏性
N-异丙基丙烯酰胺
dispersion polymerization in foam state
superporous
fast swelling
temperature sensitive
N-isopropylacrylamide
