香青兰总黄酮渗透泵片的制备及体外释药影响因素考察

Preparation and Influencing Factors on Release of Total Dracocephalum moldevica Flavonoids Osmotic Pump Tablets

目的:制备香青兰总黄酮渗透泵片,并对其体外药物释放影响因素进行研究。方法:紫外分光光度法测定渗透泵片体外释放度,考察不同处方和工艺对药物释放的影响。结果:促渗剂的种类及用量,碳酸氢钠用量,包衣增重对药物的体外释放均有显著影响。结论:渗透泵片制备工艺合理稳定,释药规律符合控释制剂要求。

Objective：To prepare total Dracocephalum moldevica flavonoids osmotic pump tablets and study its factors influencing on drug release in vitro.Method：The UV spectrophotometer was used to determine the release of the osmotic pump tablets,and various factors affected the drug release were studied.Result：The type and amount of penetration enhancers,the amount of sodium bicarbonate,and the coating weight had significant effects on release in vitro.Conclusion：The preparation of osmotic pump tablet is reasonably and stable and the formulations can meet the requirement of the controlled release drug delivery.