摘要
目的:制备香青兰总黄酮渗透泵片,并对其体外药物释放影响因素进行研究。方法:紫外分光光度法测定渗透泵片体外释放度,考察不同处方和工艺对药物释放的影响。结果:促渗剂的种类及用量,碳酸氢钠用量,包衣增重对药物的体外释放均有显著影响。结论:渗透泵片制备工艺合理稳定,释药规律符合控释制剂要求。
Objective:To prepare total Dracocephalum moldevica flavonoids osmotic pump tablets and study its factors influencing on drug release in vitro.Method:The UV spectrophotometer was used to determine the release of the osmotic pump tablets,and various factors affected the drug release were studied.Result:The type and amount of penetration enhancers,the amount of sodium bicarbonate,and the coating weight had significant effects on release in vitro.Conclusion:The preparation of osmotic pump tablet is reasonably and stable and the formulations can meet the requirement of the controlled release drug delivery.
出处
《中国实验方剂学杂志》
CAS
北大核心
2011年第6期13-16,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家科技重大专项重大新药创制(2009ZX09103-448)
关键词
香青兰总黄酮
渗透泵片
释放度
total Dracocephalum moldevica flavonoids; osmotic pump tablet; release;