摘要
目的:探讨辛芷鼻敏胶囊对变应性鼻炎(AR)大鼠骨髓及外周血中IL-5和外周血及骨髓中嗜酸性粒细胞(EOS)的影响。方法:用卵清蛋白(OVA)致敏SD大鼠制成模型,分正常对照组、模型组、鼻炎康组、辛芷鼻敏胶囊组,分别ig生理盐水、鼻炎康片(3 g·kg-1)和辛芷鼻敏胶囊(3.6 g·kg-1),连续10 d。采用双抗体夹心酶联免疫吸附技术(ELISA)定量测定骨髓及外周血中白介素-5(IL-5)含量,骨髓和外周血涂片瑞氏染色计数EOS。结果:辛芷鼻敏胶囊组骨髓及外周血中IL-5,EOS比模型组有显著降低(P<0.05),且与鼻炎康组比较有统计学意义(P<0.05);辛芷鼻敏胶囊组大鼠鼻黏膜EOS计数明显低于模型组和鼻炎康组(P<0.01,P<0.05)。结论:辛芷鼻敏胶囊可以减少IL-5水平,减少嗜酸性粒细胞浸润,而起到一定的治疗作用。
Objective：To investigate effect of Xinzhi Bimin capsule on the model of rats with allergic rhinitis（AR） and the effect on Interleukin-5（IL-5） and eosinophil（EOS）.Method：Fourty rats were randomly divided into control group,sensitized group,the positive control（Beiyankang,3 g·kg^-1） and experimental groups（3.6 g·kg^-1）.The rats were sensitized by ovalbumin.Result：IL-5 content in bone marrow of the experimental group was significantly lower than those of the model group and the positive control group（P 〈 0.05）;IL-5 content of blood serum in the experimental group was significantly lower than those of the model group and the positive control group（P 〈0.05）;the numbers of EOS,compared with the control group and the model group,there were significant difference（P 〈 0.05）.Conclusion：Xinzhi Bimin capsule can reduce IL-5 content of bone marrow and in serum,and relieve EOS infiltration.
出处
《中国实验方剂学杂志》
CAS
北大核心
2011年第6期217-219,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(30560144)
