生脉饮及其各组分提取物对大鼠离体心脏功能的影响

Effect of Shengmaiyin and its Compositions Extract on Isolated Rat Heart

目的:研究生脉饮及其各组分粗提物对离体正常及衰竭心脏心功能的影响。方法:Working Heart离体心脏灌流装置给药,冠状动脉结扎制备心肌缺血模型,多道生理记录仪测定不同药物对心功能的影响。结果:不同浓度的生脉饮均能不同程度增加正常与衰竭心脏左心室收缩最大速率及每分钟冠脉流量。人参方略好于党参方。生脉饮组分中红参与麦冬对心脏功能参数正性影响较显著,其中麦冬两组分粗提物麦冬-30、麦冬总皂苷对离体心衰模型的左心室内压最大变化速率均有较显著影响。结论:生脉饮中对离体衰竭心脏心功能起正性影响作用的主要物质为麦冬-30和麦冬总皂苷。

Objective：To study the effect of Shengmaiyin and its crude compositions extract on isolated normal and failure heart model.Method：Failure model of isolated heart was made by ligating coronary artery,then the hearts were perfused by Working Heart system.Polygraph was used to determine cardiac function affected by different drugs.Result：Shengmaiyin of different concentrations could cause the left ventricular systolic pressure,the maximum rise or decline rate of left ventricular pressure and coronary blood flow to increase in a concentration-dependent manner.Renshenfang was a little better than Dangshenfang.As compositions of Shengmaiyin,Hongshen and Ophiopogonic Radix had a positive effect on cardiac function,of which two parts of Ophiopogonis Radix crude extracts,Maidong-30 and saponin all had a great effect on left intraventricular pressure maximum alleosis rate.Conclusion：The main materials of Shengmaiyin affected positively for isolated failure heart are two compositions of Ophiopogonic Radix：Ophiopogonic Radix-30 and saponin.