一起老年病区诺如病毒医院感染暴发的调查

Outbreak of norovirus gastroenteritis in geriatrics ward

目的对北京某所三甲医院老年病区暴发的一起诺如胃肠炎医院感染进行调查。方法根据统一设计的流行病学调查表,逐一对腹泻、呕吐患者进行个案调查;收集感染者的人口统计学等信息,同时采集便标本,使用实时RT-PCR检测诺如病毒,对第二轮产物进行测序,并通过BLAST进行诺如病毒基因库比较。结果 2007年10月31日-11月12日共发生24例诺如病毒胃肠炎医院感染,包括17例住院患者,5名医务工作者及2名其他人员;该病区68.0%的患者被感染;对收集到的13份便标本进行诺如病毒检测,其中9份结果阳性,均属于GⅡ-4基因型。结论此次急性胃肠炎医院感染暴发是由诺如病毒引起的,涉及患者、医务工作者及其家属,于暴发3周后得到控制。

OBJECTIVE To investigate the outbreak of one case of noruvirus gastroenteritis in a tertiary hospital in Beijing.METHODS The patients of diarrhea and vomiting were investigated individually based on the standardized epidemiological survey form;the demographic data of infected persons were collected and the stool samples were gathered at the same time.the product of second-round was sequenced by using RT-PCR and BLAST was employed to determine the genotype of norovirus.RESULTS A total of 24 cases of noruvirus gastroenteritis outbroke from Oct 31 to Nov12,2007,involving 17 cases of inpatients,5 medical staff and 2 other relative personnel;68.0% of the patients in this ward were infected;Of 13 cases of stool samples,9 cases were positive,which belonged to GⅡ-4.CONCLUSION The outbreak of acute gastroenteritis is demonstrated to associate with norovirus,involving patients,medical staff and relatives,and it is under control in 3 weeks after the outbreak.