2006-2008年临床分离鲍氏不动杆菌的耐药性变迁

Drug resistance changes of acinetobacter baumannii isolated from 2006 to 2008

目的了解医院鲍氏不动杆菌近3年的耐药状况及分布,为临床用药及控制医院感染提供依据。方法收集医院2006年1月-2008年12月临床分离的非重复的鲍氏不动杆菌372株,采用纸片扩散法测定菌株对抗菌药物的敏感性,数据用WHONET5.4及SPSS11.5软件进行统计分析。结果鲍氏不动杆菌感染以下呼吸道感染为主,占87.4%;不同科室分离株的耐药率不同,以ICU分离株耐药率最高,占40.5%;鲍氏不动杆菌对头孢哌酮/舒巴坦的耐药率最低,为6.5%。结论 ICU分离的鲍氏不动杆菌耐药性较非ICU严重;鲍氏不动杆菌对碳青霉烯类抗菌药物耐药率明显上升,加强细菌耐药监测对抗菌药物的临床应用和控制细菌耐药性传播具有重要意义。

OBJECTIVE To investigate the prevalence and antibiotic resistance of Acinetobacter baumannii from Yuncheng City Central Hospital.METHODS A total of 372 nonduplicate strains of A.baumannii were collected from Jan 2006 to Dec 2008.Disc diffusion test was employed to study the antimicrobial resistance.And WHONET5.4 software was used for data analysis.RESULTS A.baumannii was mainly from lower respiratory tract,accounting for 87.4%.The resistance of A.baumannii varied from one department to another,and the highest was in ICU,accounting for 40.5%.The drug resistance to cefoperazone/sulbactam was the lowest with 6.5%.CONCLUSIONS The drug resistance of A.baumannii.isolated from ICU patients is more serious than that from non-ICU patients.The resistance rate of A.baumannii to carbopenems is significantly increasing.It has consequential significance to strengthen the monitoring of drug resistance of antibiotics in clinics and control the spread of bacterial drug resistance.