综合医院女性尿路感染病原菌种类及药敏分析

Pathologic bacteria that cause female urinary tract infection in general hospitals and drug susceptibility

目的探讨综合性医院女性尿路感染病原菌种类及药物敏感性,为临床医师合理使用抗菌药物提供科学依据。方法对尿路感染患者行中段尿培养,用VITEK-32微生物鉴定系统进行鉴定,药敏试验以K-B法和CLSI/NCCLS标准判读结果。结果培养分离病原菌368株,占前3位病原菌的分别为大肠埃希菌、粪肠球菌、肺炎克雷伯菌,分别占60.6%、10.9%、8.2%;革兰阴性杆菌对亚胺培南、革兰阳性球菌对万古霉素100.0%敏感,其他常用抗菌药物则有不同程度的耐药。结论革兰阴性杆菌是医院女性尿路感染的主要病原菌,临床医师应尽可能先做尿液培养,有选择的用药。

OBJECTIVE To survey the pathogenic bacteria causing female urinary tract infection in general hospitals and drug susceptibility,and to provide scientific basis for reasonable usage of antibiotics for clinicians.METHODS The clinical urine specimens from the patients with UTI were cultured.Totally 368 strains of pathogens isolated from infected urinary tract were identified by Vitek-32 auto-microbiological system and drug sensitivity testing was performed by K-B methods recommended by CLSI/NCCLS.RESULTS Among 368 strains,the top three were Escherichia coli（60.6%）,Enterococcus faecalis（10.9%） and Klebsiella pneumoniae（8.2%）.Gram-negative bacilli were 100.0% sensitive to imipenem,Gram-positive cocci were 100.0% sensitive to vancomycin.Other commonly used antibiotics had different levels of resistance.CONCLUSIONS Gram-negative bacilli are the main infectious bacteria causing female urinary tract infection in our hospital.Rational use of antibiotics should be carried out according to urine culture result.