多肽分子自组装

Molecular self-assembly of peptide

源于自然界中广泛存在的蛋白质自组装现象,近年来多肽的自组装逐渐成为材料学和生物医学等领域的研究热点.通过合理调控多肽的分子结构以及改变外界的环境,多肽分子可以利用氢键、疏水性作用、π-π堆积作用等非共价键力自发或触发地自组装形成形态与结构特异的组装体.由于多肽自身具有良好的生物相容性和可控的降解性能,利用多肽自组装技术构建的各种功能性材料在药物控制释放、组织工程支架材料以及生物矿化等领域内有着巨大的应用前景.本文总结了近年来多肽自组装研究的进展,介绍了多肽自组装技术常见的几种结构模型,概括了多肽自组装的机理,并进一步阐述多肽自组装形成的组装体形态及其在材料学和生物医学等领域里的应用.

Arising from the abundant protein self-assemblies existing in nature,recently,the self-assembly of peptides has been a research focus.Through rational designing the molecular structures of peptides and altering the external environment,peptides can spontaneously or induced self-assemble into specific-shape aggregates via noncovalent forces,such as hydrogen bonding,hydrophobic and π-stacking interactions etc.Due to well biocompatibility and controlled degradation,functional materials constructed from the self-assembly of peptides present a great potential in many biomedical fields.This review explores the research progress of the self-assembly of peptides in the past two decades.The structure motifs used in the self-assembly of peptide,self-assembly mechanisms,morphologies as well as the biomedical applications of the self-assembled peptides are also reviewed in detail.