摘要
以3-氯-6-甲基哒嗪作为起始原料,经过甲氧基化和氧化反应的次序变更,得到标题化合物的两条全新合成路线,总收率分别为28.7%和37.7%。
By using 3-chloro-6-methylpyridazine as the starting material,two new synthetic routes were realized for the preparation of 6-methoxypyridazine-3-carboxylic acid through methoxy reaction of chlorine and oxidation to carboxylic acid of methyl group in synthetic sequence changes.The overall yield of 6-methoxypyridazine-3-carboxylic acid obtained by these two routes was 28.7% and 37.7%,respectively.
出处
《化学试剂》
CAS
CSCD
北大核心
2011年第3期277-278,288,共3页
Chemical Reagents
基金
国家自然科学基金青年基金资助项目(20902071)
武汉工程大学科学研究基金资助项目(10092022)
