宫内感染致脑性瘫痪的机制研究进展

Progress of mechanisms in cerebral palsy caused by intrauterine infection

宫内感染是小儿脑性瘫痪最常见的病因之一，其对脑组织的损伤包括直接机制和间接机制。随着直接溶细胞感染、脑水肿和脑室扩大以及脑室管膜炎等直接机制的阐明，宫内感染所致脑性瘫痪的间接机制研究成为该领域的热点。除炎症介质和神经发育相关因子下凋学说外，胎盘分泌激素紊乱、Notch穿膜受体活性改变以及基因突变／缺失等也是导致脑损伤的重要因素，且各机制之间相互作用，形成网络化效应。

In recent years, many studies have claimed that the intrauterine infection is one of the most common causes of cerebral palsy. Cerebral palsy is associated with the brain injury directly or indirectly. With the direct mechanisms including breakdown of infected nerve cells of the mouse by intrauterine infection, hydrocephalus, dilation of the cerebral ventricles and ependymitis being illuminated uninterruptedly, researches of the indirect mechanism in cerebral palsy caused by intrauterine infection become the hot issue in the domain. Besides the inflammation mediators theory and down-regulated expression of development of the nervous system related factors, there were still several important elements which can cause brain damage such as placental excretive hormone imbalance, change of activity of Notch signaling and gene mutation/deletion and so on. Mechanisms and the interaction between them built up network effect.