获得性癫痫性失语研究进展

Advance in acquired epileptic aphasia

获得性癫痫性失语是一种年龄相关性癫痫综合征，是癫痫性脑病中的一种。其病凶和发病机制还不完全清楚，在发病机制方面取得的新进展主要有易患基因的发现、自身免疫反应机制及腑组织代谢异常等，但每种机制仅能解释其中的部分临床现象。治疗上，除了舒噻嗪、左乙拉西坦等新抗癫痫药的研究外，还有激素和免疫球蛋白的应用，另外还出现了饮食治疗、手语治疗及手术治疗等。

Acquired epileptic aphasia is an age-related epilepsy syndrome. It is an epileptic encephalopathy. The etiology and pathogenesis is unclear. There are many progresses in pathogens, such as of susceptibility genes, the mechanism of autoimmunity, and the disorders of metabolism in brain and so on. But each theory can only explain a part of clinic symptom. In the progress of treatments, more recent case series show that suhhiame and levetiracetam can be considered as effective drugs. There are also progresses in corticosteroid, intravenous immunoglobulims and surgery treatment. Other new methods, such as diet and sign language, are applied in clinical therapy.