摘要
病毒性心肌炎可以引起严重的心肌损伤和急性心力衰竭，进而演变成扩张型心肌病，称为炎症型心肌病。免疫系统在病毒性心肌炎向扩张型心肌病的转化中起重要作用，包括病毒RNA持续复制、免疫介导损伤和细胞凋亡等细胞免疫反应，及抗心肌抗体等体液免疫应答。临床治疗方面，除抗心力衰竭、营养心肌之外，应进一步强调利巴韦林、免疫球蛋白、α1受体阻滞剂、β受体阻滞剂、钙通道阻滞剂、血管紧张素转换酶抑制剂及螺内酯的运用。
Viral myocarditis can cause severe myocardial injury and even acute heart failure, then evolve into dilated cardiomyopathy, known as inflammatory cardiomyopathy. Immune reaction plays a key role in the transformation from viral myocarditis into dilated cardiomyopathy, including virus RNA continuous replication, immune-mediated injury, cellular apoptosis, other cellular immune response , myocardial antibodies and other humoral immune response. In the clinical treatment, besides anti-heart failure and cardiac nutrition, the use of ribavirin,α-receptor blockers, β-receptor blockers, calcium channel blockers, angiotensin converting enzyme inhibitors and spironolactone should be emphasized.
出处
《国际儿科学杂志》
2011年第2期141-143,共3页
International Journal of Pediatrics
关键词
炎症型心肌病
免疫
心肌炎
Inflammatory cardiomyopathy
Immune
Myocarditis
